Master's Thesis

Cyclic GMP: A Satiety Signal in C. elegans

Proposed model of ASI activation with cGMP signaling and TGF-β signaling pathways

About the Project

Have you ever felt like you wanted to have a bit more self-control over your appetite, but didn't know how? Or ever wonder why whenever you have a huge lunch or Thanksgiving meal, you feel so sleepy afterwards? These are just a few questions that we aimed to get to the bottom of in the You lab. Internal regulation of appetite control is required for animals to maintain their energy balance, and there are many complex molecular and neurobiological mechanisms that control it, which ultimately control animal behavior (such as getting sleepy after a huge meal). If these mechanisms are misregulated in any way, they can lead to a state of energy imbalance, such as under or overnourishment and obesity.

For my master's thesis, I carried out an independent project to investigate a part of the molecular pathway that regulates appetite control in Caenorhabditis elegans, a species of nematode and an excellent model system to study appetite and satiety control. At the end of the project, I was able to conclude that a molecular called cyclic GMP is an important part of that pathway and can be considered a satiety signal.

Read Thesis Paper